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15 High-Protein Casserole Recipes to Fuel Your Day

By: Shivani Choudhary
Updated On: January 17, 2025

You're looking for high-protein casserole recipes to boost your energy. You'll find dishes like Chicken Fajita Casserole and Beef and Broccoli Bake that combine lean protein with complex carbs. These recipes support muscle growth and weight management, making them perfect for meal prep and post-workout meals.

You're about to discover how 15 protein-packed casseroles can transform your daily routine, but first, let's take a closer look at what makes them so effective.

High-Protein Casserole Recipes

1. Chicken Fajita Casserole

A flavorful and spicy casserole filled with chicken, peppers, and onions.

Ingredients

  • 1 lb boneless, skinless chicken breasts
  • 1 large onion, diced
  • 2 large bell peppers, diced
  • 2 cloves of garlic, minced
  • 1 can of diced tomatoes
  • 1 cup of shredded cheese
  • 1/2 cup of cooked rice
  • 1 tablespoon of olive oil
  • 1 teaspoon of cumin
  • Salt and pepper to taste

Instructions

  1. Preheat the oven to 375°F (190°C).
  2. Cook the rice according to package instructions.
  3. In a large skillet, heat the olive oil and cook the diced onion and bell peppers until tender.
  4. Add the minced garlic and cook for an additional minute.
  5. Add the diced chicken to the skillet and cook until browned and cooked through.
  6. In a separate bowl, mix together the cooked rice, diced tomatoes, and shredded cheese.
  7. In a 9x13 inch baking dish, arrange a layer of the rice mixture, followed by a layer of the chicken and pepper mixture.
  8. Repeat the layers until all ingredients are used, ending with a layer of cheese on top.
  9. Bake the casserole in the preheated oven for 25-30 minutes, or until the cheese is melted and bubbly.
  10. Serve hot and enjoy.

2. Beef and Broccoli Bake

Hearty beef and broccoli casserole for a satisfying meal.

Ingredients

  • 1 pound ground beef
  • 3 cups broccoli florets
  • 1 onion, chopped
  • 2 cloves garlic, minced
  • 1 cup shredded cheddar cheese
  • 1/2 cup milk
  • 1 cup cooked rice
  • 1 teaspoon dried thyme
  • Salt and pepper to taste

Instructions

  1. Preheat oven to 350°F.
  2. Cook the ground beef in a skillet over medium-high heat until browned.
  3. Add the chopped onion and minced garlic to the skillet and cook until the onion is translucent.
  4. Add the broccoli florets to the skillet and cook until tender.
  5. In a large bowl, combine the cooked rice, shredded cheddar cheese, and milk.
  6. Add the cooked ground beef and broccoli mixture to the bowl and stir to combine.
  7. Season with salt, pepper, and dried thyme.
  8. Transfer the mixture to a 9x13 inch baking dish and bake for 25-30 minutes.
  9. Serve hot and enjoy.

3. Protein Packed Quinoa Dish

High-protein quinoa dish with chicken and vegetables.

Ingredients

  • 1 cup quinoa
  • 2 cups water
  • 1 lb boneless chicken breast
  • 1 cup mixed vegetables
  • 1/2 cup shredded cheddar cheese
  • 1/4 cup chopped fresh parsley
  • 2 tbsp olive oil
  • Salt and pepper to taste

Instructions

  1. Preheat oven to 375°F.
  2. Cook quinoa according to package instructions.
  3. Grill the chicken breast until cooked through.
  4. Sauté the mixed vegetables in olive oil until tender.
  5. In a large bowl, combine cooked quinoa, grilled chicken, and sautéed vegetables.
  6. Transfer the mixture to a baking dish and top with shredded cheese.
  7. Bake for 15-20 minutes or until the cheese is melted and bubbly.
  8. Garnish with chopped parsley and serve hot.

4. Turkey and Mushroom Meatball

Savory turkey and mushroom meatballs in a rich casserole.

Ingredients

  • 1 pound ground turkey
  • 1/2 cup mushroom duxelles
  • 1/2 cup breadcrumbs
  • 1 egg
  • 1/4 cup grated Parmesan
  • 1/4 cup chopped onion
  • 2 cloves garlic, minced
  • 1 cup marinara sauce
  • 1 cup shredded mozzarella
  • Salt and pepper, to taste

Instructions

  1. Preheat oven to 375°F.
  2. In a large bowl, combine ground turkey, mushroom duxelles, breadcrumbs, egg, Parmesan, onion, and garlic.
  3. Mix everything together with your hands or a wooden spoon until just combined.
  4. Use your hands to shape the mixture into meatballs, about 1 1/2 inches in diameter.
  5. Place the meatballs on a baking sheet lined with parchment paper.
  6. Bake the meatballs in the preheated oven for 18-20 minutes, or until cooked through.
  7. While the meatballs are baking, heat the marinara sauce in a large skillet over medium heat.
  8. When the meatballs are done, add them to the skillet with the marinara sauce.
  9. Transfer the meatballs and sauce to a 9x13 inch baking dish.
  10. Top with shredded mozzarella cheese.
  11. Return the casserole to the oven and bake for an additional 10-15 minutes, or until the cheese is melted and bubbly.
  12. Remove from the oven and let rest for a few minutes before serving.

5. Spinach and Feta Casserole

A delicious and healthy casserole packed with spinach and feta cheese.

Ingredients

  • 1 package frozen spinach, thawed and drained
  • 1 cup crumbled feta cheese
  • 1/2 cup grated cheddar cheese
  • 1/2 cup milk
  • 2 large eggs
  • 1/2 teaspoon salt
  • 1/4 teaspoon black pepper
  • 1 tablespoon olive oil
  • 1 small onion, chopped
  • 2 cloves garlic, minced

Instructions

  1. Preheat oven to 375°F (190°C).
  2. In a large skillet, heat olive oil over medium heat and sauté the chopped onion until softened.
  3. Add the minced garlic and cook for an additional minute.
  4. In a large bowl, combine the cooked spinach, feta cheese, cheddar cheese, milk, eggs, salt, and pepper.
  5. Add the cooked onion and garlic to the bowl and mix well.
  6. Pour the mixture into a 9x13 inch baking dish and smooth the top.
  7. Bake for 35-40 minutes or until the edges are golden brown and the center is set.
  8. Remove from the oven and let it cool for a few minutes before serving.

6. Shrimp and Sausage Jambalaya

Spicy shrimp and sausage jambalaya casserole with a crispy top.

Ingredients

  • 1 pound large shrimp, peeled and deveined
  • 1 pound smoked sausage, sliced
  • 1 large onion, chopped
  • 3 cloves garlic, minced
  • 1 large bell pepper, chopped
  • 2 cups uncooked white rice
  • 2 cups chicken broth
  • 1 can diced tomatoes
  • 1 teaspoon dried thyme
  • 1/2 teaspoon paprika
  • Salt and pepper, to taste
  • 2 tablespoons olive oil

Instructions

  1. Preheat oven to 400°F (200°C).
  2. Cook the sausage in a large skillet over medium-high heat until browned, about 5 minutes.
  3. Add the onion, garlic, and bell pepper to the skillet and cook until the vegetables are tender.
  4. Add the shrimp to the skillet and cook until pink, about 2-3 minutes.
  5. In a large bowl, combine the cooked sausage and shrimp mixture, rice, chicken broth, diced tomatoes, thyme, paprika, salt, and pepper.
  6. Stir in the olive oil and mix well.
  7. Transfer the mixture to a 9x13 inch baking dish and cover with aluminum foil.
  8. Bake for 25 minutes, then remove the foil and continue baking for an additional 10-15 minutes, or until the top is crispy and the casserole is hot and fluffy.
  9. Serve hot and enjoy!

7. Chicken and Rice Casserole

A classic comfort food dish with chicken, rice, and creamy sauce.

Ingredients

  • 1 1/2 cups uncooked white rice
  • 3 boneless, skinless chicken breasts
  • 2 cups mixed vegetables
  • 2 cups chicken broth
  • 1 cup shredded cheddar cheese
  • 1/2 cup milk
  • 2 tablespoons olive oil
  • 1 teaspoon dried thyme
  • Salt and pepper, to taste

Instructions

  1. Preheat oven to 350°F (180°C).
  2. Cook the rice according to package instructions.
  3. In a large skillet, heat the olive oil over medium-high heat and cook the chicken until browned.
  4. Add the mixed vegetables, chicken broth, and thyme to the skillet and bring to a boil.
  5. In a large mixing bowl, combine the cooked rice, shredded cheese, and milk.
  6. Add the cooked chicken and vegetable mixture to the bowl and stir until well combined.
  7. Transfer the mixture to a 9x13 inch baking dish and season with salt and pepper.
  8. Bake for 25-30 minutes, or until the casserole is hot and the cheese is melted.

8. Lentil and Vegetable Stew

Hearty lentil and vegetable stew packed with protein and fiber.

Ingredients

  • 1 cup dried green or brown lentils
  • 2 cups water
  • 1 onion, chopped
  • 2 cloves garlic, minced
  • 2 carrots, peeled and chopped
  • 2 potatoes, peeled and chopped
  • 1 cup diced tomatoes
  • 1 teaspoon dried thyme
  • Salt and pepper, to taste

Instructions

  1. Rinse the lentils and soak them in water for at least 30 minutes.
  2. In a large pot, heat 2 tablespoons of oil over medium heat.
  3. Add the onion and garlic and sauté until softened, about 5 minutes.
  4. Add the carrots and potatoes, and cook for an additional 5 minutes.
  5. Drain and add the lentils to the pot, along with the diced tomatoes, thyme, salt, and pepper.
  6. Pour in the water and bring the stew to a boil.
  7. Reduce heat to low and simmer, covered, for 30-40 minutes, or until the lentils are tender.
  8. Serve hot, garnished with fresh herbs, if desired.

9. Chicken Tikka Masala Bake

Creamy chicken tikka masala in a casserole form.

Ingredients

  • 1 1/2 pounds boneless chicken breast or thighs
  • 1 can of diced tomatoes
  • 1 cup of heavy cream
  • 2 tablespoons of olive oil
  • 2 teaspoons of garam masala
  • 1 teaspoon of ground cumin
  • 1/2 teaspoon of cayenne pepper
  • 1/2 teaspoon of salt
  • 1/4 teaspoon of black pepper
  • 1 cup of basmati rice
  • 1 cup of shredded mozzarella cheese
  • Fresh cilantro for garnish

Instructions

  1. Preheat oven to 375°F (190°C).
  2. Cook the basmati rice according to package instructions.
  3. In a large bowl, whisk together heavy cream, garam masala, cumin, cayenne pepper, salt, and black pepper.
  4. Add the chicken to the bowl and marinate for at least 30 minutes.
  5. Heat the olive oil in a large skillet over medium-high heat and cook the chicken until browned.
  6. In a separate saucepan, heat the diced tomatoes over medium heat.
  7. In a 9x13 inch baking dish, spread a layer of cooked rice, followed by a layer of the cooked chicken, and then a layer of the tomato sauce.
  8. Pour the remaining tomato sauce over the top and sprinkle with shredded mozzarella cheese.
  9. Bake for 25-30 minutes or until the cheese is melted and bubbly.
  10. Garnish with fresh cilantro and serve hot.

10. Breakfast Sausage Casserole

A hearty breakfast casserole filled with sausage and cheese.

Ingredients

  • 1 pound breakfast sausage
  • 1 onion, chopped
  • 2 cloves garlic, minced
  • 1 cup shredded cheddar cheese
  • 1/2 cup shredded mozzarella cheese
  • 1/2 cup milk
  • 6 eggs
  • 1 cup cubed bread
  • Salt and pepper to taste

Instructions

  1. Preheat oven to 350°F.
  2. Cook the sausage in a skillet over medium-high heat, breaking it up with a spoon as it cooks.
  3. Add the chopped onion and minced garlic to the skillet and cook until the onion is translucent.
  4. In a large bowl, whisk together the eggs, milk, salt, and pepper.
  5. Add the shredded cheddar and mozzarella cheese to the bowl and stir to combine.
  6. Add the cooked sausage and bread cubes to the bowl and stir to combine.
  7. Pour the mixture into a 9x13 inch baking dish and bake for 35-40 minutes, or until the eggs are set and the cheese is melted and golden brown.
  8. Serve hot and enjoy!

11. Chicken and Vegetable Stir

Stir-fry dish packed with chicken, vegetables, and protein.

Ingredients

  • 1 lb boneless chicken breast
  • 2 cups mixed vegetables
  • 1 cup cooked rice
  • 1/4 cup soy sauce
  • 2 tbsp olive oil
  • 1 tsp garlic powder
  • Salt and pepper to taste

Instructions

  1. Preheat oven to 375°F.
  2. Cook the chicken breast and slice into strips.
  3. Heat olive oil in a pan and stir-fry mixed vegetables.
  4. Combine cooked rice, chicken, and vegetables in a bowl.
  5. Add soy sauce and garlic powder, and mix well.
  6. Transfer the mixture to a baking dish and season with salt and pepper.
  7. Bake for 20 minutes and serve hot.

12. Mac and Cheese Casserole

Creamy macaroni and cheese baked to perfection.

Ingredients

  • 8 oz macaroni
  • 2 cups milk
  • 2 cups grated cheddar cheese
  • 1 cup grated mozzarella cheese
  • 1/4 cup all-purpose flour
  • 1/2 teaspoon salt
  • 1/4 teaspoon black pepper
  • 2 tablespoons butter

Instructions

  1. Preheat oven to 375°F.
  2. Cook the macaroni according to package instructions until al dente.
  3. In a saucepan, melt the butter over medium heat.
  4. Add the flour and whisk to make a roux, cooking for 1 minute.
  5. Slowly add the milk, whisking continuously to avoid lumps.
  6. Bring the mixture to a simmer and cook until it thickens.
  7. Remove from heat and stir in the cheddar and mozzarella cheese until melted.
  8. Combine the cooked macaroni and cheese sauce in a baking dish.
  9. Season with salt and pepper to taste.
  10. Transfer the dish to the preheated oven and bake for 20-25 minutes, or until golden brown.

13. Ground Beef Taco Bake

A hearty, cheesy casserole filled with seasoned ground beef and taco flavors.

Ingredients

  • 1 lb ground beef
  • 1 packet of taco seasoning
  • 1 can of diced tomatoes
  • 1 cup of shredded cheese
  • 1/2 cup of shredded lettuce
  • 1/2 cup of diced onions
  • 1 cup of tortilla chips, crushed
  • 1 cup of sour cream

Instructions

  1. Preheat oven to 350°F.
  2. Cook ground beef in a skillet until browned, then stir in taco seasoning.
  3. In a separate bowl, mix diced tomatoes, shredded cheese, shredded lettuce, and diced onions.
  4. In a 9x13 inch baking dish, arrange a layer of crushed tortilla chips.
  5. Add the cooked ground beef mixture on top of the tortilla chips.
  6. Add the tomato and cheese mixture on top of the ground beef.
  7. Bake for 25-30 minutes or until cheese is melted and bubbly.
  8. Remove from oven and top with sour cream.
  9. Serve hot and enjoy.

14. Chicken and Spinach Bake

A delicious and healthy casserole packed with chicken and spinach.

Ingredients

  • 1 1/2 pounds boneless, skinless chicken breast
  • 2 cups fresh spinach leaves
  • 1 cup shredded mozzarella cheese
  • 1/2 cup grated Parmesan cheese
  • 1/2 cup chopped onion
  • 2 cloves garlic, minced
  • 1 cup cherry tomatoes, halved
  • 1 tablespoon olive oil
  • Salt and pepper, to taste

Instructions

  1. Preheat oven to 375°F (190°C).
  2. Cook the chicken breast in a skillet with olive oil until browned and cooked through.
  3. In a separate skillet, sauté the chopped onion and minced garlic until softened.
  4. Add the fresh spinach leaves to the skillet and cook until wilted.
  5. In a large bowl, combine the cooked chicken, wilted spinach mixture, cherry tomatoes, mozzarella cheese, and Parmesan cheese.
  6. Mix well to combine and season with salt and pepper to taste.
  7. Transfer the mixture to a baking dish and bake for 25-30 minutes, or until the cheese is melted and bubbly.
  8. Serve hot and enjoy.

15. Turkey and Cheese Casserole

A hearty turkey and cheese casserole perfect for weeknights.

Ingredients

  • 1 pound ground turkey
  • 1 onion, chopped
  • 2 cloves garlic, minced
  • 1 cup frozen peas and carrots
  • 1 cup shredded cheddar cheese
  • 1/2 cup shredded mozzarella cheese
  • 1/2 cup milk
  • 1 cup cream of chicken soup
  • 1 teaspoon dried thyme
  • Salt and pepper, to taste
  • 1 cup crushed crackers

Instructions

  1. Preheat oven to 350°F.
  2. Cook the ground turkey in a large skillet over medium-high heat until browned, breaking it into small pieces as it cooks.
  3. Add the chopped onion and minced garlic to the skillet and cook until the onion is translucent.
  4. Stir in the frozen peas and carrots, shredded cheddar cheese, and shredded mozzarella cheese.
  5. In a separate bowl, mix the milk, cream of chicken soup, and dried thyme.
  6. Add the soup mixture to the skillet and stir until well combined.
  7. Transfer the mixture to a 9x13 inch baking dish.
  8. Sprinkle the crushed crackers over the top of the casserole.
  9. Bake for 25-30 minutes, or until the casserole is hot and the crackers are golden brown.
  10. Serve hot and enjoy.

Conclusion

You'll build muscle, boost energy, and fuel workouts with these high-protein casseroles, and you'll support weight management, enhance recovery, and satisfy cravings, making them perfect for meal prep and post-workout meals, ultimately driving results and powering progress.

Food Lover and Storyteller ????️✨ With a fork in one hand and a pen in the other, Shivani brings her culinary adventures to life through evocative words and tantalizing tastes. Her love for food knows no bounds, and she's on a mission to share the magic of flavors with fellow enthusiasts.
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